Y2 Pilots

Awarded by the American Federation for Aging Research (AFAR)

Recipient

Institution

Pilot Title

Angela Brooks
UCSC
Investigating mechanisms of oncogene-induced senescence suppression by a splicing factor mutation
Brian Diekman
UNC
The effect of stiffness on the secretory profile of senescent primary human chondrocytes
Ronald Irwin, Christian Turner
USC
Examining human Wdr23 SNPs in healthy brain aging
Kelvin Yen
USC
Investigation of a Conserved, Age-Related Mitochondrial Derived Peptide
Ryo Higuchi-Sanabria
USC
Hiding in Plain sight: the ubiquitous actin as a target for aging
Osvaldo Villa
USC
Examining age-related RNA editing responses
Constanza Cortes
UAB
Digital Profiling of Exercise-Associated Plasticity in the Aging Hippocampus
Akos Gerencser
Buck Institute
Mitochondrial regulation of pancreatic beta-cell function in aging and type 2 diabetes
Nicole Riddle
UAB
Single-nuclei transcriptional profiling of muscle in response to exercise in Drosophila
Marissa Schafer
Mayo
GeoMX Digital Spatial Profiling for discovery of senescence-related mechanisms driving dysfunction in the aged mouse brain
Stefano Tarantini
OK
Single-cell effects of time-restricted feeding in the neurovascular unit of aged mice
Yufeng Zhang
U
Characterize senescent cell secretome in selected long-lived birds and mammals

Y1 Pilots

Awarded by the American Federation for Aging Research (AFAR)

Recipient

Institution

Pilot Title

Alexander Soukas
MGH
Sgk3 associations with aging-related metabolic phenotypes
Jingjing Li
UCSF
Construct a deep convolutional neural network to computationally assign cell ages to replicative old yeast cells
Dan Winer
Buck Institute
The effects of mechanical tension on cell senescence and its secretory phenotypes
Darcie Moore
Wisconsin-Madison
Uncovering the role of intermediate filaments in stress and aging using C. elegans
Guillaume Chanfreau
UCLA
Splicing factor PRPF8 and degenerative disease phenotypes
Gordon Lithgow
Buck Institute
Analysis of polymorphisms in candidate human kinases for association with longevity and chronic neurological diseases
Weiwei Dang
Baylor
Genetic association with Alzheimer disease and neurological outcomes
Zachary Clayton
Colorado-Boulder
Using chip cytometry-based digital spatial profiling to elucidate novel mechanisms underlying aortic stiffening with aging
John Newman
Buck Institute
HMGCS2 in Human Metabolism and Health