Y2 Pilots

Recipient

Institution

Pilot Title

Angela Brooks
UCSC
Investigating mechanisms of oncogene-induced senescence suppression by a splicing factor mutation
Constanza Cortes
UAB
Digital Profiling of Exercise-Associated Plasticity in the Aging Hippocampus
Brian Diekman
UNC
The effect of stiffness on the secretory profile of senescent primary human chondrocytes
Akos Gerencser
Buck Institute
Mitochondrial regulation of pancreatic beta-cell function in aging and type 2 diabetes
Ronald Irwin, Christian Turner
USC
Examining human Wdr23 SNPs in healthy brain aging
Nicole Riddle
UAB
Single-nuclei transcriptional profiling of muscle in response to exercise in Drosophila
Ryo Higuchi-Sanabria
USC
Hiding in Plain sight: the ubiquitous actin as a target for aging
Marissa Schafer
Mayo
GeoMX Digital Spatial Profiling for discovery of senescence-related mechanisms driving dysfunction in the aged mouse brain
Stefano Tarantini
OK
Single-cell effects of time-restricted feeding in the neurovascular unit of aged mice
Osvaldo Villa
USC
Examining age-related RNA editing responses
Kelvin Yen
USC
Investigation of a Conserved, Age-Related Mitochondrial Derived Peptide
Yufeng Zhang
U
Characterize senescent cell secretome in selected long-lived birds and mammals

Y1 Pilots

Awarded by the American Federation for Aging Research (AFAR)

Recipient

Institution

Pilot Title

Bérénice Benayoun
USC
Characterizing the transposon-induced secretome in human fibroblasts
Guillaume Chanfreau
UCLA
Splicing factor PRPF8 and degenerative disease phenotypes
Zachary Clayton
Colorado-Boulder
Using chip cytometry-based digital spatial profiling to elucidate novel mechanisms underlying aortic stiffening with aging
Sean Curran, Osvaldo Villa
USC
Defining Aldh4a1 variants in muscle health of normal adult aging
Sean Curran, Nicole Stuhr
USC
Mass spec profiling of bacterial diets fed to C. elegans
Weiwei Dang
Baylor
Genetic association with Alzheimer disease and neurological outcomes
Jingjing Li
UCSF
Construct a deep convolutional neural network to computationally assign cell ages to replicative old yeast cells
Gordon Lithgow
Buck Institute
Analysis of polymorphisms in candidate human kinases for association with longevity and chronic neurological diseases
Darcie Moore
Wisconsin-Madison
Uncovering the role of intermediate filaments in stress and aging using C. elegans
John Newman
Buck Institute
HMGCS2 in Human Metabolism and Health
James Nhan, Manlio Vinciguerra
USC/ICRS-visiting scholar
Compound Screening in C. elegans for improved healthspan
Alexander Soukas
MGH
Sgk3 associations with aging-related metabolic phenotypes
Christian Turner
USC
Neuropeptide profiling of SKN-1gf mutants
Dan Winer
Buck Institute
The effects of mechanical tension on cell senescence and its secretory phenotypes