Grantees

Samuel Bailin

Vanderbilt University Medical Center

Adipose tissue aging and senescence in persons with HIV

Jordan Burton

Buck Institute for Research on Aging

Unveiling the molecular basis of longevity in honey bee flight muscle

Wilber Escorcia

Xavier

The effect of lipid buildup on genome stability of the germline

Sara Espinoza

University of Texas San Antonio

Mitochondrial microproteins response to metformin

Simon Melov/John Calambokidis

Buck/Cascadia Research Collective

Cellular resilience in an organoid muscle model of the largest animal that has ever lived

Sivana Duran Ortiz

Ohio U

Single cell resolution assessment of senescence and DNA damage response in long-lived mice with adult-onset growth hormonal receptor disruption

Paul Seidler

USC

Alzheimer's tau drug development aided by phenotypic readouts using C. elegans".

Jonathan Wanagat

UCLA

Human Translation of RNA integrity assays

Jeremy Whitson

High Point University

Examination of posttranslational modification and senescence in the aged and NDUFS4-/- mouse lens

Bérénice Benayoun

USC

Characterizing phenotypic outcomes of transposon candidate regulatory variants

Christine Charvet, Emily Graff

Auburn

Building translational tools to bridge the gap between aged humans and cats

Constanza Cortes

UAB

Geroprotective Effects of Exercise-Associated Factors on Skeletal Muscle Aging

Andrew Gordus

Johns Hopkins

The development of a cell-type atlas for young and aged spiders through scRNA sequencing.

Cristal Hill

Pennington @ LSU

The impact of a low-protein diet on protein regulation in aging mice

Derrick Morton

USC

Transcriptomic Signatures of Age-Related Neurodegeneration in Drosophila

Nicole Riddle

UAB

The Polycomb system and activity levels during aging: Establishing a link in humans

Alex Soukas

Harvard/MGH

Genetic mechanisms of lifespan and healthspan extension by metformin and phenformin

Laura Musselman

Binghamton

Genomic translation of Drosophila and human healthy aging genes

Angela Brooks

UCSC

Investigating mechanisms of oncogene-induced senescence suppression by a splicing factor mutation

Constanza Cortes

UAB

Digital Profiling of Exercise-Associated Plasticity in the Aging Hippocampus

Brian Diekman

UNC

The effect of stiffness on the secretory profile of senescent primary human chondrocytes

Akos Gerencser

Buck Institute

Mitochondrial regulation of pancreatic beta-cell function in aging and type 2 diabetes

Ronald Irwin, Christian Turner

USC

Examining human Wdr23 SNPs in healthy brain aging

Nicole Riddle

UAB

Single-nuclei transcriptional profiling of muscle in response to exercise in Drosophila

Ryo Higuchi-Sanabria

USC

Hiding in Plain sight: the ubiquitous actin as a target for aging

Marissa Schafer

Mayo

GeoMX Digital Spatial Profiling for discovery of senescence-related mechanisms driving dysfunction in the aged mouse brain

Stefano Tarantini

OK

Single-cell effects of time-restricted feeding in the neurovascular unit of aged mice

Osvaldo Villa

USC

Examining age-related RNA editing responses

Kelvin Yen

USC

Investigation of a Conserved, Age-Related Mitochondrial Derived Peptide

Yufeng Zhang

University of Memphis

Characterize senescent cell secretome in selected long-lived birds and mammals

Bérénice Benayoun

USC

Characterizing the transposon-induced secretome in human fibroblasts

Guillaume Chanfreau

UCLA

Splicing factor PRPF8 and degenerative disease phenotypes

Zachary Clayton

Colorado-Boulder

Using chip cytometry-based digital spatial profiling to elucidate novel mechanisms underlying aortic stiffening with aging

Sean Curran, Osvaldo Villa

USC

Defining Aldh4a1 variants in muscle health of normal adult aging

Sean Curran, Nicole Stuhr

USC

Mass spec profiling of bacterial diets fed to C. elegans

Weiwei Dang

Baylor

Genetic association with Alzheimer disease and neurological outcomes

Jingjing Li

UCSF

Construct a deep convolutional neural network to computationally assign cell ages to replicative old yeast cells

Gordon Lithgow

Buck Institute

Analysis of polymorphisms in candidate human kinases for association with longevity and chronic neurological diseases

Darcie Moore

Wisconsin-Madison

Uncovering the role of intermediate filaments in stress and aging using C. elegans

John Newman

Buck Institute

HMGCS2 in Human Metabolism and Health

James Nhan, Manlio Vinciguerra

USC/ICRS-visiting scholar

Compound Screening in C. elegans for improved healthspan

Alexander Soukas

MGH

Sgk3 associations with aging-related metabolic phenotypes

Christian Turner

USC

Neuropeptide profiling of SKN-1gf mutants

Dan Winer

Buck Institute

The effects of mechanical tension on cell senescence and its secretory phenotypes